Section: USMLE

31) A patient presents with cervical lymphadenopathy. Biopsy demonstrates a nodular lymphoma with follicle formation. This lesion would most likely be associated with which of the following?

1. bcr-c-abl
2. bcl-2 activation
3. c-myc activation
4. t(8, 14)
5. t(9, 22)

Nodular lymphomas of all types are derived from the B-cell line. The translocation t(14, 18), with bcl-2 activation, is associated with these lymphomas.

An abl-bcr hybrid (bcr-c-abl;) and t(9, 22) translocation are associated with chronic myeloid leukemia (CML).

c-myc activation and t(8, 14) are associated with Burkitt lymphoma.